-
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the
endogenous ligand for the
nociceptin receptor (NOP, ORL-1).
Nociceptin acts as a...
- The
nociceptin opioid peptide receptor (NOP), also
known as the
nociceptin/orphanin FQ (N/OFQ)
receptor or kappa-type 3
opioid receptor, is a
protein that...
-
endogenous opioids are dynorphins, enkephalins, endorphins,
endomorphins and
nociceptin. The
opioid receptors are ~40%
identical to
somatostatin receptors (SSTRs)...
- of the μ-, δ-, and κ-opioid receptors. It has a weak
affinity for the
nociceptin receptor.
Etorphine has an LD50 of 3 μg in humans. In Hong Kong, etorphine...
- spioxatrine, and L008716. The
pharmacology of R6890 is
described as a
nociceptin receptor (NOP) agonist,
although R6890
retains significant activity at...
-
which acts as a
potent partial agonist at both the μ-opioid
receptor and
nociceptin receptor. In
animal studies it was
found to be a
potent analgesic, with...
- of
action involved. One
major pathway being through stimulation of the
nociceptin receptor, and
blocking this
receptor may
therefore be a
means of preventing...
- bind to
kappa receptors),
endorphins (mu receptors), endomorphins, and
nociceptin-orphanin FQ. The
opioid receptors are ~40%
identical to
somatostatin receptors...
- Zhu YC, Ji RY, Cao Y (June 2000). "Study on
mechanism of
interaction of
nociceptin and
opioids binding with
opioid receptor-like 1 receptor". Acta Pharmacologica...
- Toll L (December 2009). "
Nociceptin/orphanin FQ
receptor activation attenuates antinociception induced by
mixed nociceptin/orphanin FQ/mu-opioid receptor...
