- Corey–Nicolaou
macrolactonization is a
named reaction of
organic chemistry, for the
synthesis of
lactones from
hydroxy acids,
found in 1974. The reaction...
- In
acidic Shiina macrolactonization,
Lewis acid
catalysts are used,
while nucleophilic catalysts are used for
Shiina macrolactonization under basic conditions...
- to the
formation of six-membered rings(scheme 18). Corey-Nicolaou
macrolactonization provides the
first method for
preparing medium-to-large-size lactones...
-
methods include Yamaguchi esterification,
Shiina macrolactonization, Corey-Nicolaou
macrolactonization, Baeyer–Villiger
oxidation and
nucleophilic abstraction...
- from
hydroxycarboxylic acids via
intramolecular ring
closure (Shiina
macrolactonization). The
reaction proceeds at room
temperature under basic or neutral...
- Known for
Total synthesis Nicolaou Taxol total synthesis Corey–Nicolaou
macrolactonization Awards Ernest Guenther Award (1996) Wolf
Prize in
Chemistry (2016)...
- Negrón-Silva, Guillermo; Cárdenas,
Jorge (2010). "Highly
efficient macrolactonization of ω-hydroxy
acids using benzotriazole esters:
synthesis of Sansalvamide...
-
reaction Corey–Gilman–Ganem
oxidation Corey–Kim
oxidation Corey-Nicolaou
macrolactonization Corey–Posner, Whitesides–House
reaction Corey-Seebach
reaction Corey–Winter...
- the
intramolecular cyclization of
hydroxycarboxylic acids (Shiina
macrolactonization). Both of
these intermolecular and
intramolecular reactions are used...
- professor,
discoverer of 2-Methyl-6-nitrobenzoic anhydride,
Shiina macrolactonization and
Shiina esterification Yasuhiko Kojima, virologist, discoverer...
