- Non-classical
isosteres do not obey the
above classifications, but they
still produce similar biological effects in vivo. Non-classical
isosteres may be made...
- Mills, J. S. (2003). "Chemistry
Challenges in Lead Optimization:
Silicon Isosteres in Drug Discovery". Drug
Discovery Today. 8 (12): 551–556. doi:10...
- transport. Furthermore,
their geometry and
stability make them
suitable isosteres for
benzene rings. The
classic 1964
synthesis starts with the conversion...
- Non-canonical base
pairs are
planar hydrogen bonded pairs of nucleobases,
having hydrogen bonding patterns which differ from the
patterns observed in Watson-Crick...
-
require hematological monitoring.
Investigation on a
series of
thiophene isosteres on 1 of the
phenyl rings in clozapine, a
thienobenzodiazepine analog (olanzapine)...
- is a
derivative of
anthranilic acid,: 235
which in turn is a
nitrogen isostere of
salicylic acid,
which is the
active metabolite of aspirin.: 235 : 17 ...
- the
bases pair
thanks to hydrophobicity, as
studies have
shown with DNA
isosteres (analogues with same
number of atoms) such as the
thymine analogue 2,4-difluorotoluene...
- is a
derivative of
anthranilic acid,: 235
which in turn is a
nitrogen isostere of
salicylic acid,
which is the
active metabolite of aspirin.: 235 Several...
-
control thyrotoxicosis.
Thioamides have been
incorporated into
peptides as
isosteres for the
amide bond.
Peptide modifications are
analogues of the native...
- pM at hSERT; >1000-fold
selective over hDAT, hNET, 5-HT1A, and 5-HT6.
Isosteres 3-cis-(3-Aminocyclopentyl)indole 8a: Ki = 220 pM
allosteric modulator:...
