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Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is a heme-containing
enzyme physiologically expressed in a
number of
tissues and cells...
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Indolamines are a
family of
neurotransmitters that
share a
common molecular structure.
Indolamines are a
classification of
monoamine neurotransmitter,...
- Melatonin, an
indoleamine, is a
natural compound produced by
various organisms,
including bacteria and eukaryotes. Its
discovery in 1958 by
Aaron B. Lerner...
- in
platelets and
surrounding tissue. Biochemically,
serotonin is an
indoleamine synthesized from
tryptophan and
metabolized primarily in the
liver to...
- is an
investigational drug for cancer.
Epacadostat is an
inhibitor of
indoleamine 2,3-dioxygenase-1 (IDO1).
Epacadostat inhibits IDO1 by competitively...
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tryptophan oxygenase and L-tryptophan pyrrolase) and the
closely related indoleamine 2,3-dioxygenase
enzyme (IDO). Both TDO and IDO
contain one noncovalently...
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Indoleamine 2,3-dioxygenase 2 (IDO2) is a
protein that in
humans is
encoded by the IDO2 gene. IDO2 (indolamine-2,3-dioxygenase) is an
enzyme with protein...
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arthritis under the
brand name Olumiant. As of 2016 epacadostat, an
indoleamine 2,3-dioxygenase (IDO1) inhibitor, was in
development for
various cancers...
- S,
Kuehl FA (March 1971). "Purification and
substrate specificity of
indoleamine-N-methyl transferase".
Biochemical Pharmacology. 20 (3): 712–716. doi:10...
- (September 2011). "Multiple
receptors contribute to the
behavioral effects of
indoleamine hallucinogens". Neuropharmacology. 61 (3): 364–381. doi:10.1016/j.neuropharm...
