-
Glucuronidation is
often involved in drug
metabolism of
substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids...
-
hydroxyl groups. This
linkage process is
known as
glucuronidation (or
glucuronide conjugation).
Glucuronidation occurs mainly in the liver,
although the enzymes...
- of UDP-glucuronic acid to a
small hydrophobic molecule. This is a
glucuronidation reaction.
Alternative names:
glucuronyltransferase UDP-glucuronyl transferase...
-
Biotransformation is the
biochemical modification of one
chemical compound or a
mixture of
chemical compounds.
Biotransformations can be
conducted with...
- CYP2D6 and CYP2C9 via
aromatic ring
oxidation and
glucuronidation, then
further conjugated by
glucuronidation and sulfation. The
three active metabolites exhibit...
-
bromazolam glucuronide, were
detected as
phase II metabolites.
Bromazolam N-
glucuronidation was
found to be
catalysed by UGT1A4 and UGT2B10. The
formation of...
-
glucuronosyltransferase (UDP-glucuronosyltransferase, UDPGT), an
enzyme of the
glucuronidation pathway that
transforms small lipophilic (fat-soluble) molecules, such...
- One of the
metabolites that may
result can be
formed through the
glucuronidation of galantamine. Additionally,
galantamine may
undergo oxidation or...
-
possible therapeutic applications.
Quercetin is
rapidly metabolized (via
glucuronidation)
after the
ingestion of
quercetin foods or supplements. Five metabolites...
- 6-hydroxy- and 20-dihydro-triamcinolone; most of it
probably undergoes glucuronidation, and a
smaller part sulfation.
Three quarters are
excreted via the...
