- in harvesting, and are less
expensive to manufacture.
Recombinant glucocerebrosidases used as
drugs include:
Imiglucerase (Cerezyme)
Velaglucerase (Vpriv)...
- and they are less
expensive to manufacture.
Available recombinant glucocerebrosidases are:
Imiglucerase (approved in 1995)
Velaglucerase (approved in 2010)...
-
recently been
shown to
increase activity of the
lysosomal enzyme glucocerebrosidase.
Because of this it may be a
useful therapeutic agent for both Gaucher...
-
monosaccharide head
group is glucose. In Gaucher's disease, the
enzyme glucocerebrosidase is
nonfunctional and
cannot break down
glucocerebroside into glucose...
- Israel.
Development of
taliglucerase alfa (Elelyso), a
recombinant glucocerebrosidase enzyme produced from
transgenic carrot cell cultures. Taliglucerase...
- LSD is Gaucher's disease,
which is due to
deficiency of the
enzyme glucocerebrosidase. Consequently, the
enzyme substrate, the
fatty acid glucosylceramide...
-
recently been
shown to
increase activity of the
lysosomal enzyme glucocerebrosidase, so it may be a
useful therapeutic agent for both
Gaucher disease...
-
published by the NIH:
identifying mutations in the gene that
codes for
glucocerebrosidase as a risk
factor for Parkinson's disease. In 2015, 23andMe made a...
- trauma.
Gaucher disease which is
caused by
deficiency of the
enzyme glucocerebrosidase.
Giant cell
arteritis Sympathomimetic drugs, such as amphetamine,...
- such as α-synuclein (SNCA), leucine-rich
repeat kinase 2 (LRRK2),
glucocerebrosidase (GBA), and tau
protein (MAPT) can also
cause hereditary PD or increase...
