-
hexanucleotide repeat expansion of the six
letter string of
nucleotides GGGGCC. In
approximately half of all alleles, the
hexanucleotide repeat is repeated...
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development of FTD and ALS.
These two
diseases have a
causal relationship to
GGGGCC (G4C2)
repeats within the 1st
intron of C9orf72 gene.
Normal individuals...
-
Neuron in mid-2011,
showing that a
hexanucleotide repeat expansion of the
GGGGCC genetic sequence within an
intron of this gene was responsible. This expansion...
-
lateral sclerosis and
frontotemporal dementia are
caused by
hexanucleotide GGGGCC repeat sequences in the C9orf72 gene,
causing RNA
toxicity that
leads to...
-
amyotrophic lateral sclerosis (ALS) have been
found to
develop from the
repeated GGGGCC sequence transcribed from an
intron in the C90RF72 gene.
These toxic RNA...
- Cruts, M.; Van Broeckhoven, C.; Ha****, C.; Edbauer, D. (2013). "The C9orf72
GGGGCC Repeat Is
Translated into
Aggregating Dipeptide-Repeat
Proteins in FTLD/ALS"...
-
Porphyrin Distorts RNA G-quadruplex
Structures of the Disease-****ociated r(
GGGGCC)n
Repeat of theC9orf72Gene and
Blocks Interaction of RNA-binding Proteins"...
- M,
Miller BL, Wong PC,
Petrucelli L, Kim HJ, Gao FB,
Taylor JP (2015). "
GGGGCC repeat expansion in C9orf72
compromises nucleocytoplasmic transport". Nature...
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introduced in
mouse using the BAC C9orf72 gene with the
multiple repeats of
GGGGCC. In that
study they
chose the
bacterial artificial chromosome that has the...
-
common familial form is due to an
expanded repeat of the
hexanucleotide GGGGCC at the
chromosomal locus C9ORF72. The C9ORF72
hexanucleotide repeat expansion...
