-
Fluoropyrimidines are a
general class organic compounds in
which the substituent(s)
around a
pyrimidine ring
include at
least one
fluorine atom. The term...
-
through which it acts. It
belongs to the
class of
medications known as
fluoropyrimidines,
which also
includes 5-FU and tegafur.
Capecitabine was
patented in...
-
dehydrogenase (DPD)
enzyme is
responsible for the
detoxifying metabolism of
fluoropyrimidines, a
class of
drugs that
includes 5-fluorouracil, capecitabine, and...
-
increased doses.
Subtypes of the anti-metabolites are the anti-folates,
fluoropyrimidines,
deoxynucleoside analogues and thiopurines. The anti-folates include...
-
dehydrogenase (DPD)
enzyme is
responsible for the
detoxifying metabolism of
fluoropyrimidines, a
class of
drugs that
includes 5-fluorouracil, capecitabine, and...
- (ABCC11), is a
cyclic nucleotide efflux pump and a
resistance factor for
fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine"....
-
indicated for
adults with
metastatic colorectal cancer who
received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy...
- its effectiveness.
Examples include the
fluoropyrimidines,
gemcitabine and
platinum analogs;
fluoropyrimidines increase sensitivity by
dysregulating S-phase...
- parti****nts had
received first-line
treatment with
irinotecan and
fluoropyrimidines.
Vatalanib produced no
significant improvement in
overall survival...
- properties.
Since the
synthesis of 5-fluorouracil (5-FU) in 1957,
fluoropyrimidines have been used to
treat many
types of cancer. Due to the drawbacks...
