-
farnesyl transferase, Caax
protease and
geranylgeranyl transferase I.
Farnesylation is a type of prenylation, a post-translational
modification of proteins...
-
posttranslational modifications to
become mature lamin A.
These steps include farnesylation of the carboxyl-terminal cysteine,
endoproteolytic release of the terminal...
- Parkinson's) build-up in
cells grown in the lab and in mice models.
Farnesylation Farnesene Farnesyl pyrophosphate Geranylgeraniol Nerolidol Terry Martin...
-
Meyer C,
Heinze R,
Kadereit D,
Waldmann H, et al. (November 1999). "
Farnesylation of Ras is
important for the
interaction with
phosphoinositide 3-kinase...
-
includes the
discovery of the N-Ras
oncogene , the
identification of
farnesylation of Ras proteins, and the
discovery that Ras
signals through the MAPK/ERK...
- Ras.
Farnesyltransferase inhibitors have been
developed to stop the
farnesylation of Ras and
therefore weaken its
affinity to membranes.
Other inhibitors...
- Wan J,
Dennis DT,
McCourt P, &
Huang Y (2005)
Molecular tailoring of
farnesylation for
plant drought tolerance and
yield protection.
Plant J 43:413-424...
-
addition of an
isoprenoid group (e.g.
farnesol and geranylgeraniol)
farnesylation geranylgeranylation glypiation,
glycosylphosphatidylinositol (GPI) anchor...
-
farnesol is
added to
prelamin A
using protein farnesyltransferase; this
farnesylation is
important in
targeting lamin to the
nuclear envelope,
where it maintains...
- Ras mutations) are
sensitive to
FTase inhibitors due to
inhibition of
farnesylation of a
number of
other proteins. Therefore, it is
hoped that FTIs, whilst...
