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Epoxygenases are a set of membrane-bound, heme-containing
cytochrome P450 (CYP450 or just CYP)
enzymes that
metabolize polyunsaturated fatty acids (PUFAs)...
- a
specific subset of
cytochrome P450 enzymes,
termed cytochrome P450
epoxygenases. They are
nonclassic eicosanoids. EETs are
generally short-lived, being...
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metabolizes important endogenous compounds such as
serotonin and,
owing to its
epoxygenase activity,
various polyunsaturated fatty acids,
converting these fatty...
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metabolism of
xenobiotics in the body.
Cytochrome P4502C8 also
possesses epoxygenase activity, i.e. it
metabolizes long-chain
polyunsaturated fatty acids...
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species through the
metabolism of
linoleic acid by
cytochrome P450 (CYP)
epoxygenase enzymes.
These CYPs (CYP2C9 and
probably other CYPs that
metabolize polyunsaturated...
- acid (19-HETE) (see 20-Hydroxyeicosatetraenoic acid) but also has
epoxygenase activity in that it
metabolizes docosahexaenoic acid to epoxides, primarily...
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docosahexaenoic acid (DHA). Cell
types that
express certain cytochrome P450 (CYP)
epoxygenases metabolize polyunsaturated fatty acids (PUFAs) by
converting one of their...
- 20-hydroxyeicosatetraenoic
acids (19- and 20-HETE) as
products of the
epoxygenase and ω-hydroxylase
branches of the P450 AA monooxygenase, respectively...
-
cytochrome P450
genes on
chromosome no.10 arm q24. CYP2C19 also
possesses epoxygenase activity: it is one of the prin****l
enzymes responsible for attacking...
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eicosapentaenoic acid (EPA), with
certain cytochrome P450
epoxygenases.
These epoxygenases can
metabolize EPA to as many as 10
epoxides that
differ in...
