-
Decitabine (i.e., 5-aza-2′-deoxycytidine), sold
under the
brand name
Dacogen among others, acts as a
nucleic acid
synthesis inhibitor. It is a medication...
-
Decitabine/cedazuridine, sold
under the
brand name
Inqovi among others, is a fixed-dose
combination anticancer medication used for the
treatment of adults...
-
median survival Decitabine:
Complete response rate
reported as high as 43%. A
phase I
study has
shown efficacy in AML when
decitabine is
combined with...
- and RNA.[medical
citation needed]
Azacitidine and its
deoxy derivative,
decitabine (also
known as 5-aza-2′-deoxycytidine) were
first synthesized in Czechoslovakia...
-
myeloid leukemia (AML). For this
purpose it is used with azacitidine,
decitabine, or low-dose
cytarabine for
newly diagnosed adults who are age 75 years...
-
sensitize the
tumerogenic cells to
hypomethylating chemotheraputics such as
decitabine. Many
types of
cancer (e.g. gastric) are
known for
having aberrant epigenetic...
-
Cytidine analogs such as 5-azacytidine (azacitidine) and 5-azadeoxycytidine (
decitabine) are the most
commonly used
demethylating agents. They work by inhibiting...
- DNMT inhibitors).
Currently two
members of the class,
azacitidine and
decitabine, are FDA-approved for use in the
United States in
myelodysplastic syndrome...
-
nucleotides Daunorubicin, Doxorubicin,
Epirubicin Enzyme inhibitors inhibit enzymes that are
crucial to DNA
replication Decitabine, Etoposide, Irinotecan...
-
specializing in oncology, for US$3.9 billion. This
event brought Dacogen (
decitabine),
Aloxi (palonosetron),
Hexalen (altretamine) for
ovarian cancer, and...
