- The
cyclol hypothesis is the now
discredited first structural model of a folded,
globular protein,
formulated in the 1930s. It was
based on the
cyclol reaction...
-
second hypothesis, the
cyclol hypothesis advanced by
Dorothy Wrinch,
proposed that the
linear polypeptide underwent a
chemical cyclol rearrangement C=O +...
- bond is a thiol,
hydroxyl or amine, the
resulting molecule may be
called a
cyclol or, more specifically, a thiacyclol, an
oxacyclol or an azacyclol, respectively...
-
alkaloid ergotamine, a
complex molecule consisting of a tripeptide-derived
cyclol-lactam ring
connected via
amide linkage to a
lysergic acid (ergoline) moiety...
- the
prediction of
protein structures.
Wrinch demonstrated this with the
Cyclol model, the
first prediction of the
structure of a
globular protein. Contemporary...
- a 5-HT2B
receptor antagonist. Like all ergopeptides,
bromocriptine is a
cyclol; two
peptide groups of its
tripeptide moiety are crosslinked,
forming the...
-
alkaloid ergotamine, a
complex molecule consisting of a tripeptide-derived
cyclol-lactam ring
connected via
amide linkage to a
lysergic acid (ergoline) moiety...
- the idea of the Frank–Read
source of dislocations. He also
proposed the
cyclol reaction in the mid-1930s, and made many
other contributions to solid-state...
-
using mathematical principles. She was a
champion of the
controversial '
cyclol'
hypothesis for the
structure of proteins.
Dorothy Wrinch was born in Rosario...
-
linear polymers of
amino acids rather than
branched chains, colloids, or
cyclols. He won the
Nobel Prize for this
achievement in 1958. With the development...
