- In
organic synthesis,
cyanation is the
attachment or
substitution of a
cyanide group on
various substrates. Such
transformations are high-value because...
- can
perform unique transformations on benzene, such as halogenation,
cyanation, trifluoromethylation, and hydroxylation. The
reaction was discovered...
- Theunissen,
Alexandre Pradal,
Gwilherm Evano (2016). "Copper-catalyzed
Cyanation of
Alkenyl Iodides". Org. Synth. 93: 163. doi:10.15227/orgsyn.093.0163...
- base or an enzyme.
Because of the
hazards with HCN,
other less
dangerous cyanation reagents are
often used.
Trimethylsilyl cyanide,
affording the
silyl ether...
-
exhibits some
biological activity. It is
prepared from
benzaldehyde by
amino cyanation (Strecker synthesis). It can also be
prepared from
glyoxal and by reductive...
- pesticides, such as
mustard oil.
Illustrative of its
reactivity is its
cyanation to
allyl cyanide (CH2=CHCH2CN).
Being a
reactive alkyl halide, it undergoes...
- reagent.
Glyceraldehyde is a
precursor to four-carbon
sugars (tetroses) via
cyanation followed by
hydrolysis of the cyanohydrin: HOCH2CH(OH)CH(OH)CN + 2 H2O...
- water, but is
stable in
aqueous mineral acid.
Synthesis of DDQ
involves cyanation of chloranil. J.
Thiele and F. Günther
first reported a 6-step preparation...
-
Searle AD (2017). "An
Evaluation of
Multiple Catalytic Systems for the
Cyanation of 2,3-Dichlorobenzoyl Chloride:
Application to the
Synthesis of Lamotrigine"...
- cancer. 4-(trifluoromethyl)benzonitrile,
produced by the
Nickel catalyzed cyanation of 4-chlorobenzotrifluoride is a
precursor for the
antidepressant Fluvoxamine...
