-
toxicity are also modified. Non-classical
bioisosteres may
differ in a
multitude of ways from
classical bioisosteres, but
retain the
focus on
providing similar...
-
Chemistry of Drug
Design and Drug Action,
Second Edition, 2004
Nathan Brown.
Bioisosteres in
Medicinal Chemistry. Wiley-VCH, 2012, p. 237. ISBN 978-3-527-33015-7...
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biochemistry and
medicinal chemistry,
phosphonate groups are used as
stable bioisosteres for phosphate, such as in the
antiviral nucleotide analog, Tenofovir...
- MacMillan,
David W. C. (June 2023). "General
access to
cubanes as
benzene bioisosteres". Nature. 618 (7965): 513–518. doi:10.1038/s41586-023-06021-8. ISSN 1476-4687...
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Meanwell NA (March 2011). "Synopsis of Some
Recent Tactical Application of
Bioisosteres in Drug Design".
Journal of
Medicinal Chemistry. 54 (8): 2529–91. doi:10...
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Bioisosteres in
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Tomaszewski Z,
Johnson MP,
Huang X,
Nichols DE (May 1992). "Benzofuran
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- a
tetrazole which is
being used in
place of the
carboxylic acid as a
bioisostere.
Losartan is used for hypertension,
including in
people with left ventricular...
-
including several cephalosporin-class antibiotics.
Tetrazoles can act as
bioisosteres for
carboxylate groups because they have
similar pKa and are deprotonated...
-
substituted thiophenes and
thiazoles are more
potent still, as they are
closer bioisosteres to the 4-carbomethoxy
group of carfentanil. Side
effects of fentanyl...
