-
Arrestins (abbreviated Arr) are a
small family of
proteins important for
regulating signal transduction at G protein-coupled receptors.
Arrestins were...
-
Arrestin, beta 1, also
known as ARRB1, is a
protein which in
humans is
encoded by the ARRB1 gene.
Members of
arrestin/beta-
arrestin protein family are...
- Beta-
arrestin-2, or β-arrestin2, also
known as
arrestin beta-2, is an
intracellular protein that in
humans is
encoded by the ARRB2 gene.
Members of...
- The
arrestin family of
proteins is
subdivided into α-
arrestins (also
referred to as
arrestin-related
trafficking adaptors (ARTs) or
arrestin-like yeast...
- phosphorylation, the GPCR's
affinity for β-
arrestin (β-
arrestin-1/2 in most tissues) is increased, at
which point β-
arrestin may bind and act to both sterically...
-
inhibitory protein,
arrestin, then
binds to the
phosphorylated rhodopsins to
further inhibit the
rhodopsin activity.
While arrestin shuts off rhodopsin...
- SBI-553 is an
experimental drug
which acts as both a β-
arrestin biased positive allosteric modulator and also a Gα-biased
negative allosteric modulator...
- of an
arrestin protein to the receptor.
Phosphorylated serine and
threonine residues in
GPCRs act as
binding sites for and
activators of
arrestin proteins...
- N-(2-propargyloxy)-2,5-dimethoxy-4-(dimethylamino)phenethylamine, is a β-
arrestin-biased
serotonin 5-HT2A
receptor agonist of the phenethylamine, 2C, and...
- receptors. Both 7-OH-MIT and
mitragynine do not
appear to
activate the β-
arrestin pathway,
distinguishing it from
traditional opiate and
opioid chemicals...
