Definition of Apurinic. Meaning of Apurinic. Synonyms of Apurinic

- In biochemistry and molecular genetics, an AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA (also in RNA but much...
- The enzyme DNA-(apurinic or apyrimidinic site) lyase, also referred to as DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase (systematic name)...
- GC tautomers. Depurination – Loss of a purine base (A or G) to form an apurinic site (AP site). Deamination – Hydrolysis changes a normal base to an atypical...
- rate. When depurination occurs with DNA, it leads to the formation of apurinic site and results in an alteration of the structure. Studies estimate that...
- phosphodiester backbone of DNA, followed by inaccurate repair or replication of the apurinic site leading to mutation and eventually cancer. This genotoxic mechanism...
- activation-induced (cytidine) deaminase (AID), uracil DNA glycosylase and apyrimidic/apurinic (AP)-endonucleases. AID begins the process of class switching by deaminating...
- DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene. Apurinic/apyrimidinic (AP) sites (also called "abasic...
- oxygen species increase leading to the ac****ulation of DNA damages such as apurinic/apyrimidinic sites and double-strand breaks. Also in non-replicating cells...
- Apurinic/apyrimidinic (AP) endonuclease is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main role in the repair of damaged...
- enzyme, uracil-DNA glycosylase, followed by cleavage of the DNA backbone by apurinic endonuclease. Error-prone DNA polymerases are then recruited to fill in...