-
Antifolates are a
class of
antimetabolite medications that
antagonise (that is, block) the
actions of
folic acid (vitamin B9).
Folic acid's
primary function...
-
Salvage pathways are
targets for drug development, one
family being called antifolates. A
number of
other biologically-important substances, like methionine...
-
appear to be
extremely rare.
Trachtman JN,
Pagano V (December 2015). "
Antifolates and MTHFR".
Therapeutic Drug Monitoring. 37 (6): 697–698. doi:10.1097/FTD...
- in
structure to the
metabolite that they
interfere with, such as the
antifolates that
interfere with the use of
folic acid; thus,
competitive inhibition...
-
children with ALL.
Remissions were brief, but the
principle was
clear —
antifolates could suppress proliferation of
malignant cells, and
could thereby re-establish...
- uses
active site
mutants in
BaDHFR to
guide lead
optimization for new
antifolate inhibitors. DHFR has been used as a tool to
detect protein–protein interactions...
- Kwon, Yun Kyung; Higgins,
Meytal B.; Rabinowitz,
Joshua D. (2010). "
Antifolate-Induced
Depletion of
Intracellular Glycine and
Purines Inhibits Thymineless...
- for toxicity. Ciclosporin, may
increase plasma levels of ciclosporin.
Antifolates such as trimethoprim, methotrexate,
pemetrexed and raltitrexed. Hypoglycemics...
-
Hemozoin inhibitors Antifolates Sesquiterpene lactones artemether#
artemisinin artemotil artesunate#
dihydroartemisinin Other atovaquone (+ proguanil)...
- They are
treated after the
first trimester because pyrimethamine has an
antifolate effect, and lack of
folic acid can
interfere with
fetal brain formation...
