-
Aggrecanases are
extracellular proteolytic enzymes that are
members of the
ADAMTS (A
Disintegrin And
Metalloprotease with
Thrombospondin Motifs) family...
-
encoded by this gene
contains two C-terminal TS
motifs and
functions as
aggrecanase to
cleave aggrecan, a
major proteoglycan of cartilage. ADAMTS5 may also...
-
proteoglycans in
articular cartilage in osteoarthritis.
Which of
these aggrecanases is more
important in
cartilage degradation appears to be species-specific...
- ADAMTS-4
endopeptidase (EC 3.4.24.82,
aggrecanase-1) is an enzyme. This
enzyme catalyses the
following chemical reaction Glutamyl endopeptidase; bonds...
- Kurz B,
Sandy JD,
Grodzinsky AJ (February 2000). "Mannosamine
inhibits aggrecanase-mediated
changes in the
physical properties and
biochemical composition...
- activity,
mediated by
factors including matrix metalloproteinases and
aggrecanases.
Traumatic rupture or detachment: The
cartilage in the knee is frequently...
-
development of arthritis.
Proteases capable of
degrading aggrecans are
called aggrecanases, and they are
members of the ADAM (A
Disintegrin And Metalloprotease)...
-
cartilage from
patients with
osteoarthritis and
appears to
suppress ADAMTS4 (
aggrecanase) activity,
possibly leading to
cartilage cell (chondrocyte) cloning....
- Collins-Racie LA,
Flannery CR, Zeng W, et al. (2005). "ADAMTS-8
exhibits aggrecanase activity and is
expressed in
human articular cartilage".
Matrix Biol...
- ISSN 1063-4584.
Malfait AM,
Tortorella MD (2019-09-17). "The "elusive DMOAD":
Aggrecanase inhibition from
laboratory to clinic".
Clinical and
Experimental Rheumatology...
