-
Wortmannin, a
steroid metabolite of the
fungi Penicillium funiculosum,
Talaromyces wortmannii, is a non-specific,
covalent inhibitor of phosphoinositide...
-
inhibited by the
drugs wortmannin and LY294002,
although certain members of the
class II PI3K
family show
decreased sensitivity.
Wortmannin shows better efficiency...
-
potent than
wortmannin,
another well-known PI3
kinase inhibitor. However, LY294002 is a
reversible inhibitor of PI3K
whereas wortmannin acts irreversibly...
-
intramolecular aldol reaction in the ring
closure step for
total synthesis of (+)-
Wortmannin by Shigehisa, et al. (Figure 2). Klein,
David R. (December 22, 2020)....
- edge in
osteogenic differentiation.
Wortmannin is a PI3K-specific inhibitor, and
treatment of
cells with
Wortmannin in
combination with PDGF
resulted in...
- BY
WORTMANNIN, LY294002, QUERCETIN,
MYRICETIN AND
STAUROSPORINE 1e7v:
STRUCTURE DETERMINANTS OF
PHOSPHOINOSITIDE 3-KINASE
INHIBITION BY
WORTMANNIN, LY294002...
-
activation of the PKB/mTOR
pathway in
normal adipocytes treated with
wortmannin and in
adipocytes from db/db mice".
FASEB Journal. 18 (15): 1894–6. doi:10...
- ligand. The
formation of
these vesicles is
sensitive to
inhibition by
wortmannin[citation needed] The
initiation of
vesicle formation can be dela****/inhibited...
- mutations. All PI 3-kinases are
inhibited by the
drugs wortmannin and LY294002 but
wortmannin shows better efficiency than LY294002 on the
hotspot mutation...
- an
anamorph species of
fungus in the
genus Penicillium which produces wortmannin.
MycoBank Straininfo of
Penicillium proteolyti**** ATCC V.
Betina (1993)...
