-
Taxanes are a
class of diterpenes. They were
originally identified from
plants of the
genus Taxus (yews), and
feature a
taxadiene core. Pa****axel (Taxol)...
- (mBC) in
patients who have been
treated previously with
trastuzumab and a
taxane (pa****axel or docetaxel), and who have
already been
treated for mBC or...
- In enzymology, a
taxane 10beta-hydroxylase (EC 1.14.13.76) is an
enzyme that
catalyzes the
chemical reaction taxa-4(20),11-dien-5alpha-yl
acetate + NADPH...
- In enzymology, a
taxane 13alpha-hydroxylase (EC 1.14.13.77) is an
enzyme that
catalyzes the
chemical reaction taxa-4(20),11-dien-5alpha-ol +
NADPH + H+...
- pa****axel or docetaxel. The core
carbon skeleton of a
normal natural product taxane (e.g., pa****axel, docetaxel) has a 6-membered A ring, 8-membered B ring...
- and
include important compounds such as retinol,
phytol or taxadiene.
Taxanes are
class of
diterpenoids featuring a
taxadiene core. They are produced...
-
liver problems. Use
during pregnancy may harm the baby.
Docetaxel is in the
taxane family of medications. It
works by
disrupting the
normal function of microtubules...
- unresectable, and/or
metastatic breast cancer who
received prior trastuzumab and
taxane therapy for
metastatic disease or
developed disease recurrence during or...
-
agents include taxanes and epothilones, both of
which prevent cancer cells from
dividing by
interfering with tubulin.
While taxanes like Pa****axel and...
- that use
during pregnancy may
cause birth defects. Pa****axel is in the
taxane family of medications. It
works by
interference with the
normal function...
