- perinatally.
SynGAP1 is
shown to
localize at the
postsynaptic density on the
dendritic spines of
excitatory synapses.
Cultured neurons of
SynGAP heterozygotic...
-
autosomal dominant genetic disorder caused by
haploinsufficiency of the
SynGAP protein,
usually due to the
presence of a
heterozygous protein-truncating...
-
behavioural abnormalities.
Additional molecules thought to be
involved include SynGAP and SHANK1. Mark,
Leighton P; Prost,
Robert W; Ulmer, John L; Smith, Mic****e...
- homolog-****ociated
protein 4". Kim JH, Liao D, Lau LF,
Huganir RL (1998). "
SynGAP: a
synaptic Ras
GAP that ****ociates with the PSD-95/SAP90
protein family". Neuron...
- GTPase-activating
protein (
synGAP) by Ca2+/calmodulin-dependent
protein kinase II (CaMKII) and cyclin-dependent
kinase 5 (CDK5)
alters the
ratio of its
GAP activity toward...
- domain, and a C-terminal (C) domain. ULK2 and the
GTPase activating protein SynGAP function cooperatively in axon formation. Yan J,
Kuroyanagi H, Tomemori...
- PMID 12576483. Kim JH, Liao D, Lau LF,
Huganir RL (Apr 1998). "
SynGAP: a
synaptic Ras
GAP that ****ociates with the PSD-95/SAP90
protein family". Neuron...
-
Synapsin 1; Synaptobrevin/VAMP;
Synaptojanin 1; Synaptophysin; Synaptotagmin;
synGAP; Synphilin-1;
Syntaxin 1;
Syntaxin 2;
Syntaxin 3;
Syntaxin 4; Synuclein...
-
Rumbaugh G (2008).
Reduced expression of the NMDA receptor-interacting
protein SynGAP causes behavioral abnormalities that
model symptoms of schizophrenia....
- PMID 14499480.
Krapivinsky G,
Medina I,
Krapivinsky L,
Gapon S,
Clapham DE (2004). "
SynGAP-MUPP1-CaMKII
synaptic complexes regulate p38 MAP
kinase activity and NMDA...
