- two
sirtuins,
eukaryotes encode several sirtuins in
their genomes. In yeast, roundworms, and fruitflies, sir2 is the name of one of the
sirtuin-type...
-
characterized by a
sirtuin core
domain and
grouped into four classes. The
functions of
human sirtuins have not yet been determined; however,
yeast sirtuin proteins...
- However, non-histone
proteins can be
deacetylated by
sirtuins as well.
These activities of
sirtuins are
particularly interesting because of
their importance...
-
Sirtuin-activating
compounds (STAC) are
chemical compounds having an
effect on
sirtuins, a
group of
enzymes that use NAD+ to
remove acetyl groups from...
-
Preliminary research indicates that
sirtuins are
activated by
fasting and
serve as "energy sensors"
during metabolism.
Sirtuins,
specifically Sir2 (found in...
-
transcriptional level,
sirtuins also
directly control the
activity of
metabolic enzymes. In
Salmonella enterica, the
bacterial sirtuin CobB
regulates the...
- on NAD+ as co-factor of
enzymatic activities. SIRT5 is one of the
three sirtuins localized primarily to the mitochondrion.
Alternative splicing of this...
- The
enzymatic activity of Sirt6, as well as of the
other members of the
sirtuins family, is
dependent upon the
binding of the
cofactor nicotinamide adenine...
- unsettled.
Because NADH is a
cofactor for
processes inside mitochondria, for
sirtuins and PARP, NMN has been
studied in
animal models as a
potential neuroprotective...
-
phosphate synthetase I (CPS I),
interacts with a
class of
molecules called sirtuins, NAD
dependent protein deacetylases, and ATP to form
carbamoyl phosphate...
