- 2018,
there was no
clinical evidence that
sirtuins affect human aging.
Yeast Sir2 and some, but not all,
sirtuins are
protein deacetylases.
Unlike other...
-
transcriptional level,
sirtuins also
directly control the
activity of
metabolic enzymes. In
Salmonella enterica, the
bacterial sirtuin CobB
regulates the...
-
characterized by a
sirtuin core
domain and
grouped into four classes. The
functions of
human sirtuins have not yet been determined; however,
yeast sirtuin proteins...
-
Sirtuin-activating
compounds (STAC) are
chemical compounds having an
effect on
sirtuins, a
group of
enzymes that use NAD+ to
remove acetyl groups from...
- However, non-histone
proteins can be
deacetylated by
sirtuins as well.
These activities of
sirtuins are
particularly interesting because of
their importance...
- striatum, hippocampus, and
spinal cord.
Studies suggest that the
human sirtuins may
function as
intracellular regulatory proteins with mono-ADP-ribosyltransferase...
- The
enzymatic activity of Sirt6, as well as of the
other members of the
sirtuins family, is
dependent upon the
binding of the
cofactor nicotinamide adenine...
- on NAD+ as co-factor of
enzymatic activities. SIRT5 is one of the
three sirtuins localized primarily to the mitochondrion.
Alternative splicing of this...
-
Preliminary research indicates that
sirtuins are
activated by
fasting and
serve as "energy sensors"
during metabolism.
Sirtuins,
specifically Sir2 (found in...
-
human cDNAs with
homology to the
yeast SIR2 gene: Sir2-like
proteins (
sirtuins)
metabolize NAD and may have
protein ADP-ribosyltransferase activity"....
