-
amino acids glycine and proline. This is the
collagen precursor procollagen. Then,
procollagen is
modified by the
addition of
hydroxyl groups to the amino...
- Type II
collagen is the
basis for
hyaline cartilage,
including the
articular cartilages at
joint surfaces. It is
formed by
homotrimers of collagen, type...
-
Procollagen-proline dioxygenase,
commonly known as
prolyl hydroxylase, is a
member of the
class of
enzymes known as alpha-ketoglutarate-dependent hydroxylases...
-
cells as a pre-
procollagen. The
signal peptide is
cleaved off
producing a
procollagen molecule.
Three identical type III
procollagen chains come together...
-
modifications in
order to make the
final type I
collagen product. The
procollagen complex is then
modified by
different enzyme proteinases which cleave...
- peptidase,
aminoterminal procollagen peptidase,
procollagen aminoterminal protease,
procollagen N-terminal proteinase, type I/II
procollagen N-proteinase, type...
-
Lysyl hydroxylases (or
procollagen-lysine 5-dioxygenases) are alpha-ketoglutarate-dependent
hydroxylases enzymes that
catalyze the
hydroxylation of lysine...
-
reaction Cleavage of the C-terminal
propeptide at Ala-Asp in type I and II
procollagens and at Arg-Asp in type III This
endopeptidase belongs to the peptidase...
-
fibrosis through downregulation of the
production of
growth factors and
procollagens I and II. It was
first approved in ****an for the
treatment of people...
- domains, in
particular the amino-terminal heparin-binding domain, the
procollagen domain, the properdin-like type I repeats, and the
globular carboxy-terminal...
