- SLC6A12, SLC6A13
Pericyte unknown unknown lymph node None None
unknown None
PDGFRalpha+, PDGFRbeta+
Plasma Cell
unknown unknown lymph node None None unknown...
- five ligands, PDGF-AA
through -DD (including -AB), and two receptors,
PDGFRalpha and PDGFRbeta. All
PDGFs function as secreted, disulphide-linked homodimers...
-
McBride M, Al-Moamen NJ,
Finkelman FD, et al. (September 2008). "FIP1L1/
PDGFRalpha synergizes with SCF to
induce systemic mastocytosis in a
murine model...
- diseases.
Imatinib has been
reported to be an
effective treatment for FIP1L1-
PDGFRalpha+ mast cell disease,
hypereosinophilic syndrome, and dermatofibrosarcoma...
- 1038/ng1415. PMID 15361870.
Olson LE,
Soriano P (February 2009). "Increased
PDGFRalpha activation disrupts connective tissue development and
drives systemic...
-
Bonifas JM,
Zachary C,
Epstein E,
McCormick F (July 2001). "A role of
PDGFRalpha in
basal cell
carcinoma proliferation". Proc Natl Acad Sci U S A. 98 (16):...
- et al. (2006). "Activation of FIP1L1-
PDGFRalpha requires disruption of the
juxtamembrane domain of
PDGFRalpha and is FIP1L1-independent". Proc. Natl...
-
congenital diaphragmatic hernia from
animal models:
sequencing of FOG2 and
PDGFRalpha reveals rare
variants in
diaphragmatic hernia patients". Eur. J. Hum....
