- substrates,
NRTIs and
NtRTIs lack a 3′-hydroxyl
group on the
deoxyribose moiety. As a result,
following incorporation of an NRTI or an
NtRTI, the next incoming...
- of
nucleoside and
nucleotide reverse-transcriptase
inhibitors (NRTIs and
NtRTIs)
began in the 1980s when the AIDS
epidemic hit
Western societies. NRTIs...
-
NRTIs and
NtRTIs act as
competitive substrate inhibitors.
Examples of
NRTIs include zidovudine, abacavir, lamivudine, emtricitabine, and of
NtRTIs – tenofovir...
-
orally administered nucleotide analog reverse-transcriptase
inhibitor (
ntRTI). It can be
formulated as the
pivoxil prodrug adefovir dipivoxil. It is...
-
transcriptase inhibitors (NRTIs),
nucleotide reverse transcriptase inhibitors (
NtRTIs), Non-nucleoside
reverse transcriptase inhibitors (NNRTIs),
protease inhibitors...
- date
Health Canada approval date
Company Single-tablet regimen?
NRTIs /
NtRTIs NNRTI INSTI PI PK
enhancer Combivir lamivudine zidovudine September 26,...
- Elvucitabine†
Islatravir (EFdA, ISL)§ Racivir† Stampidine†
Nucleotide analogues/
NtRTIs:
Tenofovir disoproxil (TDF)#
Tenofovir alafenamide (TAF) Non-nucleoside...
-
Tenofovir disoproxil is a
nucleotide analog reverse-transcriptase
inhibitor (
NtRTI). It
selectively inhibits viral reverse transcriptase, a
crucial enzyme...
- Elvucitabine†
Islatravir (EFdA, ISL)§ Racivir† Stampidine†
Nucleotide analogues/
NtRTIs:
Tenofovir disoproxil (TDF)#
Tenofovir alafenamide (TAF) Non-nucleoside...
-
tenofovir that
functions as a
nucleotide reverse transcriptase inhibitor (
NtRTI).
Other prodrugs for
tenofovir have been tested, but TAF is more efficient...
