-
NAPQI, also
known as
NAPBQI or N-acetyl-p-benzoquinone imine, is a
toxic byproduct produced during the
xenobiotic metabolism of the
analgesic paracetamol...
-
known as
NAPQI (N-acetyl-p-benzoquinone imine).
NAPQI is
responsible for the
liver toxicity of paracetamol. At
usual doses of paracetamol,
NAPQI is quickly...
- itself, but from one of its metabolites, N-acetyl-p-benzoquinone
imine (
NAPQI).
NAPQI decreases the liver's
glutathione and
directly damages cells in the...
-
converted to
NAPQI. The
conjugation of
NAPQI to
glutathione occurs until glutathione is
depleted from
hepatic reserves,
after which the
toxic NAPQI ac****ulates...
-
imine (
NAPQI).
NAPQI is a
reactive metabolite formed by the
action of
cytochrome P450 on
paracetamol (acetaminophen).
Glutathione conjugates to
NAPQI, and...
-
large quantities, a
minor metabolite called N-acetyl-p-benzoquinone
imine (
NAPQI) ac****ulates
within the body. It is
normally conjugated by glutathione,...
- the drug
itself but to a
toxic metabolite (N-acetyl-p-benzoquinone
imine (
NAPQI))
produced by
cytochrome P-450
enzymes in the liver. In
normal cir****stances...
-
metabolite NAPQI via the
cytochrome P450
oxidase system,
mainly by the
subfamily CYP2E1.
Hepatic reduced glutathione (GSH) will
detoxify this
formed NAPQI quickly...
-
which may be
exogenous toxins or
produced in the
course of
metabolism (e.g.
NAPQI from paracetamol). https://www.newscientist.com/article/mg18224443...
- have the
highest concentration of CYP2E1 and thus are most
sensitive to
NAPQI production in
acetaminophen toxicity.
Other zonal injury patterns include...
