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Mertansine, also
called DM1 (and in some of its
forms emtansine), is a thiol-containing
maytansinoid that for
therapeutic purposes is
attached to a monoclonal...
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Lorvotuzumab mertansine (IMGN901) is an antibody-drug conjugate. It
comprises the CD56-binding antibody,
lorvotuzumab (huN901), with a
maytansinoid cell-killing...
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Cantuzumab mertansine (SB-408075; huC242-DM1) is an antibody-drug
conjugate investigated to
treat colorectal cancer and
other types of cancer. It is a...
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Bivatuzumab mertansine is a
combination of bivatuzumab, a
humanized monoclonal antibody, and
mertansine, a
cytotoxic agent. It is
designed for the treatment...
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Alemtuzumab Belantamab mafodotin Bevacizumab Bivatuzumab mertansine§ Brontictuzumab§
Cantuzumab mertansine§
Cantuzumab ravtansine§
Cirmtuzumab Citatuzumab bogatox§...
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inhibitors monomethyl auristatin A MMAE,
monomethyl auristatin F MMAF and
mertansine, DNA
binder calicheamicin and
topoisomerase 1
inhibitors SN-38 and exatecan...
- It uses a more
hindered disulfide linkage than
cantuzumab mertansine.
Cantuzumab mertansine ImmunoGen Inc,
developer of DM4
based drugs World Health Organization...
-
several cytotoxic agents,
yielding antibody-drug conjugates :
Cantuzumab mertansine Cantuzumab ravtansine "HuC242
binds to the
extracellular domain of the...
- (INN)
bitolterol (INN)
bitoscanate (INN)
bivalirudin (INN)
bivatuzumab mertansine (INN)
bixalomer (USAN, INN)
bizelesin (INN)
Blenoxane (Bristol-Myers Squibb)...
-
Kadcyla DM1
attached to an
antibody with ImmunoGen's SPP
linker is
called "
mertansine". DM4
attached with ImmunoGen's SPDB
linker is
called "ravtansine" indatuximab...
