-
Mercapturic acids are
condensation products formed from the
coupling of
cysteine with
aromatic compounds. They are
formed as
conjugates in the
liver and...
-
example is the
processing of
glutathione conjugates to
acetylcysteine (
mercapturic acid) conjugates. Here, the γ-glutamate and
glycine residues in the glutathione...
- glutathione; this
detoxification produces acrylic acid, butanol, and
mercapturic acid waste,
which is excreted.
Exposure can
occur through inhalation...
- of
toluene exposure. As its name indicates, is a
benzyl derivative of
mercapturic acid (acetylcysteine). Inoue, O; Kanno, E; Kasai, K; Ukai, H; Okamoto...
- non-toxic
conjugate APAP-GSH is
taken up in the bile and
further degraded to
mercapturic and
cysteine conjugates that are
excreted in the urine. In overdose,...
- WB (1974). "Glutathione S-transferases. The
first enzymatic step in
mercapturic acid formation". J Biol Chem. 249 (22): 7130–7139. doi:10.1016/S0021-9258(19)42083-8...
- rodents. The
detoxification reactions comprise the
first four
steps of
mercapturic acid synthesis, with the
conjugation to GSH
serving to make the substrates...
- a
toxic substance of
Lampteromyces ****onicus:
urinary excretion of
mercapturic acids in rat". Xenobiotica. 26 (3): 347–354. doi:10.3109/00498259609046713...
-
These glycidamide-glutathione
conjugates are
further metabolized to
mercapturic acids by
various peptidases and transferases, such as gamma-glutamyl-transpeptidase...
- Klotz, Katrin; Angerer, Jürgen (2016). "Quantification of
naphthoquinone mercapturic acids in
urine as
biomarkers of
naphthalene exposure".
Journal of Chromatography...
