- A
megakaryocyte (mega- + karyo- + -cyte, "large-nucleus cell") is a
large bone
marrow cell with a
lobated nucleus that
produces blood platelets (thrombocytes)...
- the bone
marrow cells that bud off
large numbers of platelets.
Megakaryocytopoiesis is the
cellular development process that
leads to
platelet production...
-
Thrombopoietin Kimura H,
Ohkoshi T,
Matsuda S,
Uchida T,
Kariyone S (1988). "
Megakaryocytopoiesis in
polycythemia vera:
characterization by
megakaryocytic progenitors...
- in
blood cells:
correlation with
various leukemias and
abnormal megakaryocytopoiesis".
Proceedings of the
National Academy of
Sciences of the
United States...
- S,
Tenza D, Caen JP (April 1990). "Negative
regulation of
human megakaryocytopoiesis by
human platelet factor 4 and beta thromboglobulin: comparative...
- IL-10.
Interleukin 11 (IL-11) is a
secreted protein that
stimulates megakaryocytopoiesis,
initially thought to lead to an
increased production of platelets...
-
Cosman D,
Vainchenker W., « Mpl
ligand is a
humoral regulator of
megakaryocytopoiesis », Nature, 1994 jun 16;369(6481), p. 571-4
Methia N,
Louache F, Vainchenker...
- (Eosinophil precursor) Megakaryocyte-erythroid
progenitor cell (MEP)
Megakaryocytopoiesis CFU-Meg
Megakaryoblast Promegakaryocyte Megakaryocyte Thrombopoiesis...
- The
primary hematopoietic activity of
Neumega is
stimulation of
megakaryocytopoiesis and thrombopoiesis. In mice and
nonhuman primate studies Neumega...
-
cloned in 1994.
Thrombopoietin was
shown to be the
major regulator of
megakaryocytopoiesis and
platelet formation. The
protein encoded by the c-mpl gene, CD110...
