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Somatic hypermutation (or SHM) is a
cellular mechanism by
which the
immune system adapts to the new
foreign elements that
confront it (e.g. microbes)...
-
experimental results in the
fields of epigenetics, genetics, and
somatic hypermutation demonstrated the
possibility of
transgenerational epigenetic inheritance...
-
promotes B cell proliferation,
immunoglobulin class switching, and
somatic hypermutation as well as
sustains T cell
growth and differentiation. T cell-derived...
- Reed–Sternberg
cells have
undergone both V(D)J
recombination and
somatic hypermutation,
establishing an
origin from a
germinal center or
postgerminal center...
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undergo a high rate of
point mutation, by a
process called somatic hypermutation (SHM). SHM
results in
approximately one
nucleotide change per variable...
- proliferate, differentiate, and
mutate their antibody genes (through
somatic hypermutation aimed at
achieving higher affinity)
during a
normal immune response;...
-
specialised structures called germinal centers. This
process involves somatic hypermutation,
resulting in
genetic changes that
enhance the antibody's affinity....
- (AID) that is
essential for
class switch recombination and
somatic hypermutation. He was
elected as a
foreign ****ociate of the
National Academy of Sciences...
-
immunoglobulin of
germinal center B
cells and as a
direct result of
somatic hypermutation (SHM) and
selection by TFH cells. The
process is
thought to involve...
-
normally engulf B
cells that have
undergone apoptosis after somatic hypermutation. In some
people with SLE,
significantly fewer TBMs can be found, and...
