Definition of Endothelins. Meaning of Endothelins. Synonyms of Endothelins

- Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium having a key role in vascular homeostasis. Endothelins are...
- is proteolytically processed to release endothelin 1. Endothelin 1 is one of three isoforms of human endothelin. Preproendothelin is precursor of the peptide...
- 656–63. doi:10.1016/0006-291X(91)90158-4. PMID 1713452. Vane J (1991). "Endothelins come home to roost". Nature. 348 (6303): 673. doi:10.1038/348673a0. PMID 2175394...
- There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation...
- An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Three main kinds of ERAs exist: selective ETA receptor antagonists...
- (1997). "Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells"...
- been shown to release local chemicals called endothelins which are powerful vasoconstrictors. Endothelins help to regulate capillary exchange and alter...
- taken by mouth. Aprocitentan is a dual endothelin-1 antagonist that targets both endothelin A and endothelin B receptors. Aprocitentan was approved for...
- Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. Endothelin receptor type A has been shown to interact with HDAC7A...
- and Leu7 instead of Leu6 and Met7) it was often ****umed that the two endothelins were similar in synthetic pathway and mechanism of action. As ET-1 is...