- The
desmogleins are a
family of
desmosomal cadherins consisting of
proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the
formation of desmosomes...
-
Desmoglein-1 is a
protein that in
humans is
encoded by the DSG1 gene.
Desmoglein-1 is
expressed everywhere in the skin epidermis, but
mainly it is expressed...
-
Desmoglein-2 is a
protein that in
humans is
encoded by the DSG2 gene.
Desmoglein-2 is
highly expressed in
epithelial cells and cardiomyocytes. Desmoglein-2...
-
Desmoglein-3 is a
protein that in
humans is
encoded by the DSG3 gene. In the skin
epidermis Desmoglein-3 is
expressed in the
basal lower layers of the...
- The
extracellular core region,
approximately 34 nm in length,
contains desmoglein and desmocollin,
which are in the
cadherin family of cell
adhesion proteins...
-
Desmoglein-4 is a
protein that in
humans is
encoded by the DSG4 gene. List of
conditions caused by
problems with
junctional proteins GRCh38:
Ensembl release...
-
autoimmune disease caused by
antibodies directed against both
desmoglein 1 and
desmoglein 3
present in desmosomes. Loss of
desmosomes results in loss of...
- pemphix,
meaning "blister". In pemphigus,
autoantibodies form
against desmoglein,
which forms the "glue" that
attaches adjacent epidermal cells via attachment...
-
desmoglein 1. The
effect of the
antibodies and the
immunological pathway is most
likely one of
three mechanisms:
Steric hindrance of the
desmoglein 1:...
-
Exfoliating toxins are
serine proteases that
specifically bind to and
cleave desmoglein 1 (Dsg1).
Previous studies suggested that
exfoliating toxins bind to gangliosides...
