-
effecting alkylation.
Alkyl groups can also be
removed in a
process known as
dealkylation.
Alkylating agents are
often classified according to
their nucleophilic...
-
synthesis of 4,4'-biphenol via the
oxidative coupling and
subsequent dealkylation of 2,6-di-tert-butylphenol. Friedel–Crafts
acylation involves the acylation...
-
prepared by
dealkylation of
alkylated pyridines,
which are
obtained as
byproducts in the
syntheses of
other pyridines. The
oxidative dealkylation is carried...
- used due to it
being a
primary metabolite, the
product of
hepatic N-
dealkylation, of MDMA. It is also a
common adulterant of
illicitly produced MDMA....
- (COMT)-catalyzed
methylation or glucuronide/sulfate conjugation; and (2) N-
dealkylation, deamination, and
oxidation to the
corresponding benzoic acid derivatives...
- reaction.
Evidence also
exists for a
carbocation based mechanism of
dealkylation similar to an SN1 reaction,
where the R1
group initially dissociates...
- para-hydroxylation,
aliphatic alpha- and beta-hydroxylation, N-oxidation, N-
dealkylation, and deamination. The
known metabolic pathways include: Methamphetamine...
- para-hydroxylation,
aliphatic alpha- and beta-hydroxylation, N-oxidation, N-
dealkylation, and deamination. The
known metabolic pathways,
detectable metabolites...
- electron-withdrawing
group (EWG). The
reaction proceeds by
nucleophilic dealkylation of the
ester by the
halide followed by decarboxylation,
followed by hydrolysis...
-
binding of
anastrozole is 40%. The
metabolism of
anastrozole is by N-
dealkylation, hydroxylation, and glucuronidation.
Inhibition of
aromatase is due to...
