- The
second type of
coenzymes are
called "
cosubstrates", and are
transiently bound to the protein.
Cosubstrates may be
released from a
protein at some point...
-
Smart cosubstrates are an
elegant solution for
thermodynamically limited redox reactions and have many advantages: Less
conventional cosubstrates (e.g...
- to
cytochrome P450 enzymes. Both use O2 and
reducing equivalents as
cosubstrates and both
generate water. αKG-dependent
hydroxylases have
diverse roles...
-
known under the
commercial names of SAMe, SAM-e, or AdoMet, is a
common cosubstrate involved in
methyl group transfers, transsulfuration, and aminopropylation...
- of sulfate, as a
competitive inhibitor of ATP sulfurylase. PAPS is a
cosubstrate and
source of
activated sulfate for both
cytosolic sulfotransferases...
-
conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a
cosubstrate for
homocysteine remethylation to methionine.
Natural variation in this...
-
being tightly linked to the apoprotein. Not to be
confused with the
cosubstrate that
binds to the
enzyme apoenzyme (either a
holoprotein or heteroprotein)...
-
Pseudomonas syringae,
mediates fosfomycin resistance by
using ATP as
cosubstrate".
Antimicrobial Agents and Chemotherapy. 39 (7): 1569–1573. doi:10.1128/aac...
-
limits NO
production by eNOS. Instead, eNOS
reacts with oxygen,
another cosubstrates involved in NO production. The
products of eNOS are
reduced to superoxides...
- "Mechanism of
sirtuin inhibition by nicotinamide:
altering the NAD(+)
cosubstrate specificity of a Sir2 enzyme".
Molecular Cell. 17 (6): 855–68. doi:10...
