- The
second type of
coenzymes are
called "
cosubstrates", and are
transiently bound to the protein.
Cosubstrates may be
released from a
protein at some point...
- A
smart cosubstrate is a type of
cosubstrate used for
cofactor regeneration to
yield greater productivity and
lower environmental impact (E-factor). A...
-
known under the
commercial names of SAMe, SAM-e, or AdoMet, is a
common cosubstrate involved in
methyl group transfers, transsulfuration, and aminopropylation...
- to
cytochrome P450 enzymes. Both use O2 and
reducing equivalents as
cosubstrates and both
generate water. αKG-dependent
hydroxylases have
diverse roles...
-
being tightly linked to the apoprotein. Not to be
confused with the
cosubstrate that
binds to the
enzyme apoenzyme (either a
holoprotein or heteroprotein)...
-
Pseudomonas syringae,
mediates fosfomycin resistance by
using ATP as
cosubstrate".
Antimicrobial Agents and Chemotherapy. 39 (7): 1569–1573. doi:10.1128/aac...
- of sulfate, as a
competitive inhibitor of ATP sulfurylase. PAPS is a
cosubstrate and
source of
activated sulfate for both
cytosolic sulfotransferases...
- 6‐hexanediol as a ‘double‐smart
cosubstrate’ More
efficient redox biocatalysis by
utilising 1, 4-butanediol as a ‘smart
cosubstrate’ A fed‐batch
synthetic strategy...
-
conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a
cosubstrate for
homocysteine remethylation to methionine.
Natural variation in this...
- "Mechanism of
sirtuin inhibition by nicotinamide:
altering the NAD(+)
cosubstrate specificity of a Sir2 enzyme".
Molecular Cell. 17 (6): 855–68. doi:10...
