-
Amylin, or
islet amyloid polypeptide (IAPP), is a 37-residue
peptide hormone. It is co-secreted with
insulin from the
pancreatic β-cells in the
ratio of...
- The
amylin receptors (AMYRs) are
heterodimers of the
calcitonin receptor that are
bound to by
amylin with high
affinity and
consist of AMY1, AMY2, and...
-
Amylin Pharmaceuticals, Inc. is a
biopharmaceutical founded in 1987 that was
based in San Diego, California. The
company was
engaged in the discovery,...
- Dual
amylin and
calcitonin receptor agonists (DACRAs) are a
class of
drugs that act as
agonists at the
amylin receptor and
calcitonin receptor that are...
- of
Langerhans responsible for the
production and
release of
insulin and
amylin.
Constituting ~50–70% of
cells in
human islets, beta
cells play a vital...
-
Cagrilintide is a long-acting
analogue of
amylin. It is
being tested to
treat obesity and type 2
diabetes by
itself and in
combination with semaglutide...
- (trade name Symlin) is an
injectable amylin analogue drug for
diabetes (both type 1 and 2),
developed by
Amylin Pharmaceuticals (now a
wholly owned subsidiary...
- In
molecular biology, the
amylin protein family or calcitonin/CGRP/IAPP
protein family is a
family of proteins,
which includes the
precursors of calcitonin/calcitonin...
- diabetes. CCL2
induces amylin expression through ERK1/ERK2/JNK-AP1 and NF-κB
related signaling pathways independent of CCR2.
Amylin upregulation by CCL2...
-
amylin, a
peptide hormone co-secreted with
insulin from the
pancreatic β cells. As
plasma glucose levels recede, the
subsequent reduction in
amylin secretion...
