- An
enamine is an
unsaturated compound derived by the
condensation of an
aldehyde or
ketone with a
secondary amine.
Enamines are
versatile intermediates...
- The
Stork enamine alkylation involves the
addition of an
enamine to a
Michael acceptor (e.g., an α,β -unsaturated
carbonyl compound) or
another electrophilic...
- pattern. Non-carbon
nucleophiles such as water, alcohols, amines, and
enamines can also
react with an α,β-unsaturated
carbonyl in a 1,4-addition. Some...
- reactions. In 1963, G.
Stork reported the
first enamine alkylation reaction for
ketones -
Stork enamine alkylation reaction. In 1976,
Meyers reported the...
- CH3),
classified as an
enamine. It is a
colorless liquid.
Primary and
secondary enamines tend to isomerize, but
tertiary enamines are
kinetically stable...
- the β
carbon of the β-ketoesters (2), and
eventually forming an
enamine (3). The
enamine then
attacks the
carbonyl carbon of the α-haloketone (4). This...
-
aldehydes toward nucleophilic addition by
formation of
enamines (e.g. used in the
Stork enamine alkylation):
International Union of Pure and
Applied Chemistry...
- ketone)
initially forms a
phenylhydrazone which isomerizes to the
respective enamine (or 'ene-hydrazine').
After protonation, a
cyclic [3,3]-sigmatropic rearrangement...
-
titanium tetrachloride. In the
Stork enamine alkylation,
secondary amines form
enamines when
exposed to ketones.
These enamines then
react (possibly enantioselectively)...
-
bonded are far more common.
Isothiazones are
produced by
oxidation of
enamine-thiones. The ring
structure of
isothiazole is
incorporated into larger...
